Correspondence to Michel de Lorgeril PRETA – TIMC – IMAG, Equipe Coeur & Nutrition, Faculté de Médecine, Domaine de la Merci, Université de Grenoble, 38706 La Tronche, France; michel.delorgeril{at}ujf ...

Objectives Systematic reviews and meta-analyses are the foundation of modern evidence-based medicine and their use is becoming more prolific than randomised trials. However, systematic reviews are ...

Evidence-informed decision-making (EIDM) refers to the systematic and transparent process of identifying, appraising and mobilising the best available evidence to inform the development of safe and ...

Objectives Cancer overdiagnosis is a polarizing topic, with much disagreement on its drivers, magnitude, and implications. Overdiagnosis is also complex, as various factors interact to influence said ...

As a heart surgeon, you regularly perform aortic valve replacement, using a median sternotomy technique. However, you are aware that less-invasive options are available, and you wonder whether these ...