San Francisco 49ers star Deebo Samuel had a blunt reaction when asked about his low numbers to begin this season.

With the Bills (9-2) on the cusp of a fifth straight AFC East division title, the pressure is on Allen and Co. to deliver the ...

The Bills attempt to win seven in a row when they host the 49ers in this Week 13 NFL odds, prediction, and pick.

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on “Sunday Night Football” in Week 13. The ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

Now that the holiday season is in full swing, several Bills players are taking the time to be active in the community. A ...

Simpson carried the ball 29 times against the Lions and set a new NFL record with 273 rushing yards, breaking his own record ...

Save big on all your favorite team gear, from jerseys to hats, with incredible discounts that'll have you ready for game day.

San Francisco 49ers defensive end Nick Bosa missed Wednesday's practice as the team began preparations for Sunday's game ...

Bills' QB Josh Allen is the current favorite for MVP. Expectations aren't something I like to make a habit. However, it's ...

While the 49ers look like an easy opponent, San Francisco's health could be a major factor in the game, warns one NFL expert.

The Bills and 49ers meet on Sunday Night Football in a game with playoff implications for both teams. Here are three ...