Christian McCaffrey had 107 yards from scrimmage in his season debut. The 49ers are a different team when McCaffrey is on the ...

The craziest storyline all year with the 49ers centered around Pearsall, a first-round draft pick who survived a gunshot ...

San Francisco treaded water without Christian McCaffrey. Now that the NFL's reigning Offensive Player of the Year is back, it ...

Cornerback Deommodore Lenoir, who has emerged as a cornerstone of the defense, agreed to a five-year extension.

San Francisco 49ers tight end George Kittle has two objectives for this season — remain healthy and win a Super Bowl.

Former Oregon Ducks cornerback Deommodore Lenoir is now among the highest paid at his position in the National Football ...

NFL Week 11 odds, picks, predictions, TV and streaming information for the Sunday football game between the Seattle Seahawks ...

Knox argues San Francisco 49ers safety Talanoa Hufanga could be just what the Saints defense has been missing: Injuries have ...

The San Francisco 49ers and Seattle Seahawks will face off in a NFC West showdown this Sunday, and if you want to attend the ...

Kyle Shanahan’s expression said it all as Sunday’s game for the San Francisco 49ers against the Tampa Bay Buccaneers. A win ...

Looking at Sunday’s Seattle Seahawks at San Francisco 49ers Week 11 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers just spent a week away from the football field for leisure. Now, they will head to the warm beaches ...