Brock Purdy revealed what he thought about while standing on the sideline at the of the San Francisco 49ers' loss to the ...

Neil Reynolds, Jeff Reinebold and Phoebe Schecter discuss San Franciscos playoff prospects on the Inside The Huddle Pofcast; ...

The Buffalo Bills (9-2) take a six-game winning streak into their contest with the San Francisco 49ers on Sunday, December 1, ...

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

The results were ugly for the San Francisco 49ers last week against the Green Bay Packers without starting quarterback Brock ...

Dive into the San Francisco 49ers vs. Buffalo Bills showdown with a look at odds, predictions, and the best betting options.

It looks like the San Francisco 49ers might get their quarterback back under center in time for a Week 13 matchup with the ...

San Francisco 49ers vs Buffalo Bills showdown with essential stats, lineup predictions and injury updates you won’t want to ...

Purdy's status would have a massive impact on the outcome of the game. Backup quarterback Brandon Allen, who started in Purdy ...

The San Francisco 49ers promoted CB Nick McCloud to the active roster from the team's practice squad and activated LB Jalen ...

The NFL's two best running backs meet Sunday in a potential Super Bowl preview. Seattle, Arizona and San Francisco also have ...

San Francisco's starting quarterback missed last week's loss to the Packers. Here's the latest on whether he'll play in primetime on Sunday.