Five NFL teams have the chance to exit September with an unblemished record, but each will be tested. Here are USA TODAY Sports' Week 4 picks.

There are some large spreads on the board in Week 4, so let’s take a look at each matchup (with the favorites listed in parentheses) and run through our best Week 4 spread bets. Odds are courtesy of DraftKings Sportsbook and subject to change.

Before looking at SportsbookWire staff’s Week 4 NFL picks, here are the against-the-spread (ATS) and Over/Under (O/U) leaders, according to Teamrankings.com.