San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

The Buffalo Bills have shared a clip of intense snow covering Highmark Stadium ahead of their game with the San Francisco ...

The San Francisco 49ers will take on the Buffalo Bills in the Week 13 edition of NBC's "Sunday Night Football." What to know ...

The 49ers expect to have Brock Purdy back in the starting lineup for Week 13. We break down the fantasy football implications ...

"Sunday Night Football" in Week 13 sees the San Francisco 49ers taking on the Buffalo Bills. Here's the latest on a snowy ...

Right there, leading the AFC East and sitting in second place in the conference with a 9-2 record, are the Buffalo Bills.

The Buffalo Bills are asking for snow shovelers to help shovel out Highmark Stadium in anticipation of the winter weather in ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

The #Bills have activated Pro Bowl LB Matt Milano off Injured Reserve and he’ll play on Sunday against the #49ers for the ...

The Buffalo Bills (9-2) take a six-game winning streak into their contest with the San Francisco 49ers on Sunday, December 1, ...

The Buffalo Bills have activated Matt Milano from injured reserve, putting the starting linebacker in position to play Sunday ...

The Bills also announced that they are elevating quarterback Mike White and tight end Zach Davidson from the practice squad.